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. The latest version of Yaroze is version 1.001.17.. The latest full version of Yaroze is version 1.1.0.. The latest Yaroze 2.1.1 Beta.1.17 is available to download from the link below .The influence of metabolic activity in donor and recipient tissues on the neointima, media, and adventitia in allografts. An autoradiographic study.
The effects of acute ischemia on the microvascular and cellular structure of heterotopic allografts were studied in the rat. Wistar-Lauda allografts were transplanted to Wistar recipients for 7 days, before being reperfused. The results indicate that ischemia affects all graft structures in different ways. There were striking differences between the anastomotic region and the non-anastomotic regions of the graft. Whereas severe tissue necrosis was observed in all non-anastomotic regions, the anastomotic region showed only mild to moderate necrotic changes. Acellular, cellular and cellular-fibrous thrombi were observed in the non-anastomotic regions. The dynamics of acute ischemia-induced vascular necrosis and microanatomical changes were quantified using 3H-tritiated proline incorporation and 3H-proline plus 3H-tritiated proline as markers of collagen synthesis and degradation, respectively. The results show a significant, more rapid degradation of collagen in the anastomotic region than in the non-anastomotic regions. The differences in collagen breakdown were not matched by differences in collagen synthesis. The collagen breakdown and the accumulation of thrombi in the non-anastomotic regions were enhanced by an ischemic period of 24 h, whereas collagen synthesis was inhibited. The dynamics of collagen breakdown and tissue necrosis in the non-anastomotic regions were not influenced by ischemic pretreatment in the recipient animals. The relationship of these findings to microvascular changes was investigated by light and electron microscopy. Ischemia caused a significant reduction in microvascular patency, and microvascular occlusion was more extensive in the non-anastomotic than in the anastomotic region. In conclusion, the results indicate that acute ischemia affects all tissue structures in different ways, but as a general rule tissue injury in the non-anastomotic
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