EmbriologiaClinicaMoorepdf

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EmbriologiaClinicaMoorepdf

 

Moore, Keith L

22

UNPUBLISHED PUBLISHED PUBLISHED

712

Embriología clínica

Abstract.
Although rheumatic heart disease is eradicated in industrialized countries, it is the most important cause of morbidity and mortality in developing countries. Genetically, rheumatic heart disease is complex, caused by gene-gene and gene-environmental interactions. Nod-like receptor pyrin domain containing 3 (NLRP3) inflammasome has been strongly associated with rheumatic heart disease but, the mechanisms involved are not fully explained. Our aim was to determine whether NLRP3 inflammasome activation, in paracrine and autocrine fashion, is involved in epithelial-mesenchymal transition (EMT) of cardiac fibroblasts and its consequences in the formation of extracellular matrix and collagen I expression. We cultured human cardiac fibroblasts with bovine serum albumin (BSA) and evaluated whether BSA induced NLRP3 inflammasome activation and established its relation to pro-inflammatory IL-1β and IL-18. We also evaluated the effect of NLRP3 and its agonists on TGF-β1 and collagen I expression and fibroblast to myofibroblast transition (FMT). Our results showed that BSA induced NLRP3 inflammasome activation in human cardiac fibroblast and this activation was associated with IL-1β and IL-18 secretion. In cardiac fibroblasts, NLRP3 inflammasome activation, induced by its agonists, was associated with increased IL-1β and IL-18 secretion, a significant reduction in TGF-β1 and collagen I expression and an induction of FMT. These data showed that NLRP3 inflammasome activation in cardiac fibroblast promotes inflammatory, fibrotic and pro-fibrogenic response through EMT, which could be considered therapeutic targets for rheumatic heart disease. The findings also suggest that NLRP3 inflammasome could be used as a risk marker in population susceptible to rheumatic heart disease.

Abstract.
According to the current nosological classification of depressive disorders, major depressive disorder (MDD), dysthymia and depressive symptoms are included in the same group of affective disorders. The aim of this study was to compare the clinical characteristics, mood symptoms, and brain morphology in depressive https://chat.byoe.tv/upload/files/2022/06/NyoTeNU1aFOAkYNDS8BF_07_f777a0020a4e371103439b529c2e8c7f_file.pdf

 

Keith L Moore – Embriología clínica, Bol.
Download Embriología Clinica Arteaga (Información para el usuario) ebook, pdf, epub txt or read without registration. Editor: Keith L Moore. Published: 2016-10-23.
Keith L Moore – Embriología clínica, Bol. Books Medicos – Ultradeepay.
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Embriología Clinica Arteaga. Download PDF. « oEmbriologia Clinica Arteaga » Doctorando en medicina y embriología. de las condiciones de crecimiento y desarrollo del bebé en la vida embrionaria.
Olivia L. Johnston, PhD”. Moore, KS.
Embriología Clinica Arteaga [Internet] (Spanish Edition).
Embriología y embriología clínica by Moore…
Embriología. Fácilmente. huérfanos y embriología, por encargo de Difundir el conocimiento de los procesos de crecimiento y diferenciación infantiles y enriquecer la
Keith L Moore – Embriología.
Nuevo ed. del libro que se ha convertido en un clásico, Embriología Clinica Arteaga (Spanish Edition). Keith Moore – Embriología, Bol. · mas…Más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más… · más…
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